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庞巧兰[1] 李庆刚[2][1]山东鲁抗医药集团公司,济宁272021 [2]山东大学发酵工程国家重点实验室,济南250100摘 要:目的
对青霉素发酵罐的接种工艺进行改进。方法 打破种罐种子演接种控制在10～15％的传统，接入2096的种罐种子液和1096的发酵至60h的前期发酵液，使总接种量达到3096。结果与结论
配合发酵前期工艺优化，可使发酵指数提高10．8％，提炼收率提高0．496，发酵提炼的生产指数提高11．296。[著者文摘]
关键词:青霉素 发酵罐 种罐 接种量
分类号: TQ460.6[著者标引]文献标识码：A文章编号：1672-7738（2005）07-0571-03栏目信息：医药工业
相关文献:主题相关
Improved inoculation of Penicillin fermenterPang Qiao-lan,Li
Qing-gang (1.Shandong Lukang Pharmaceutical Conglomerate
Company,Ji'ning,272021 ;2. State Key Lab of Fermentation
Engineering, Shandong University,Ji' nan,250100)Pang Qiao-lan,Li
Qing-gang (1.Shandong Lukang Pharmaceutical Conglomerate
Company,Ji'ning,272021 ;2. State Key Lab of Fermentation
Engineering, Shandong University,Ji' nan,250100)Abstract:Objective
To improve the inoculation technique of Penicillin fermenter.
Methods Traditional inoculation of Penicillin fermenter
used seed broth with a inoculation volume of 10-15 %. Under
improved inoculation,this volume was raised to 20% ,at the
same time fermentation broth of earlier stage was inoculated
and overall inoculation volume were reached to 30%. Results
and Conclution Combining the base of optimization of fermentation
earlier stage,it showed that fermentation index had increased
10.8 %, refinement yield increased 0.4 %, production index
of fermentation and refinement increased 11.2 %.
Key words:Penicillin;fermentor;seed tank;inoculation volume |
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